Characteristics of nitric oxide-mediated cholinergic modulation of calcium current in rabbit sino-atrial node
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چکیده
منابع مشابه
Role of nitric oxide on the electrophysiological properties of isolated rabbit atrioventricular node by extracellular field potential during atrial fibrillation
Introduction: The aim of the present study was to determine direct effects of NO modulation on protective electrophysiological properties of atrioventricular node (AV node) in the experimental model of AF in rabbit. Methods: Isolated perfused rabbit AV nodal preparations were used in two groups. In the first group (N=7), LNAME (50μM) was applied. In the second group (N=12), different concent...
متن کاملFacilitation of the L-type calcium current in rabbit sino-atrial cells: effect on cardiac automaticity.
OBJECTIVE The L-type Ca(2+) current (I(Ca,L)) contributes to the generation and modulation of the pacemaker action potential (AP). We investigated facilitation of I(Ca,L) in sino-atrial cells. METHODS Facilitation was studied in regularly-beating cells isolated enzymatically from young albino rabbits (0.8-1 kg). We used the whole-cell patch-clamp technique to vary the frequency of the test de...
متن کاملCurrent-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine
"Funny" (f-) channels have a key role in generation of spontaneous activity of pacemaker cells and mediate autonomic control of cardiac rate; f-channels and the related neuronal h-channels are composed of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel subunits. We have investigated the block of f-channels of rabbit cardiac sino-atrial node cells by ivabradine, a novel heart ...
متن کاملEffect of nitric oxide modulation on the basic and rate-dependent electrophysiological properties of AV-node in the isolated heart of rabbit: The role of adrenergic and cholinergic receptors
Introduction: Recent studies showed that nitrergic system have specific modulatory effects on electrophysiological properties of atrioventricular (AV) node. The aim of this study was to determine the effects of nitric oxide (NO) on the electrophysiological properties of isolated rabbit AV node and to investigate the role of adrenergic and cholinergic receptors in the mechanism of its action...
متن کاملrole of nitric oxide on the electrophysiological properties of isolated rabbit atrioventricular node by extracellular field potential during atrial fibrillation
introduction: the aim of the present study was to determine direct effects of no modulation on protective electrophysiological properties of atrioventricular node (av node) in the experimental model of af in rabbit. methods: isolated perfused rabbit av nodal preparations were used in two groups. in the first group (n=7), lname (50μm) was applied. in the second group (n=12), different concentrat...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1998
ISSN: 0022-3751
DOI: 10.1111/j.1469-7793.1998.741bm.x